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Selection and progression of unimolecular agonists at the GIP, GLP-1, and glucagon receptors
Retatrutide remains investigational, with Phase 3 trials ongoing and potential approval not expected until mid-2026 or 2027 at the earliest
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An additional mechanism may be nausea/vomiting, which was shown to have a minimal effect on weight loss in a post hoc mediation analysis of semaglutide vs exenatide extended release and dulaglutide in the SUSTAIN 3 and 7 trials [45]
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